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  • Title: [Calcium channel blockers in heart failure].
    Author: Hole T, Dickstein K, Gundersen T, Kjekshus J, Myhre ES, Rønnevik PK, Westheim AS.
    Journal: Tidsskr Nor Laegeforen; 1997 Jun 20; 117(16):2329-32. PubMed ID: 9265278.
    Abstract:
    Patients with heart failure are particularly susceptible to the negative effects of calcium channel blockers because the failing heart demonstrates a defect in the delivery of calcium to the contractile proteins, and an attenuation of the normal sympathetic reflexes. Currently these drugs have no place in the treatment of heart failure caused by systolic dysfunction of the left ventricle. Calcium channel blockers should probably not be described for patients with coronary artery disease and left ventricular dysfunction. When the patient needs additional treatment for angina and beta-blockers or nitrates have not given satisfactory results, it may be appropriate to prescribe amlodipine or felodipine.
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