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  • Title: Phenoxyacetic acid induces glutathione-dependent detoxification and depletes the glutathione pool in Penicillium chrysogenum.
    Author: Emri T, Pócsi I, Szentirmai A.
    Journal: J Basic Microbiol; 1997; 37(3):181-6. PubMed ID: 9265740.
    Abstract:
    Enzymes of the glutathione-dependent detoxification pathway (glutathione S-transferase and gamma-glutamyl-transpeptidase) were induced, and the glutathione pool was completely depleted by phenoxyacetic acid in Penicillium chrysogenum mycelia incubated for 15 h in a culture medium containing lactose as a carbon source and sodium glutamate as a nitrogen source. A significant increase in both the oxidised glutathione concentrations and the glutathione reductase activities were also observed. 1-Chloro-2,4-dinitrobenzene--a potent substrate and inducer of glutathione S-transferase-initiated very similar physiological changes but no beta-lactam production could be detected in this case. When (NH4)2HPO4 was used as a nitrogen source the penicillin biosynthesis was repressed and the induction of gamma-glutamyltranspeptidase by phenoxyacetic acid was hindered considerably.
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