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  • Title: [Clinico-electrocardiographic, morphological and biochemical manifestations of glycoside poisoning in patients with myocardial infarct].
    Author: Popov VG, Smetnev AS, Lazutin VK, Beskrovnova NN, Zhelnov VV.
    Journal: Kardiologiia; 1977 Sep; 17(9):26-34. PubMed ID: 926596.
    Abstract:
    The clinical manifestations of glycoside toxicosis were compared with the character of myocardial ultrastructural changes and the electrolyte shifts outside the infarction zone. Accumulation of glycogen in the cytoplasm of the muscle cells with simultaneous gross destruction of the myocardial ultrastructure in the pre-infarction zones are morphological manifestations of glycoside toxicosis on the ultrastructural level. The administration of strophanthin to patients with extremely severe cardiac insufficiency due to myocardial infarction may lead to disturbance in the mitochondrial energy-producing activity and the development of nodes of myofibril over-contractility with subsequent death of the cell, even to the development of smallfocal necrosis in the myocardium. The use of lidocaine and panangin in sufficiently high doses is an effective measure in the prevention and elimination of extrasystolic arrhythmias caused by glycoside toxicosis.
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