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  • Title: The demonstration of serum interleukin-8 and superoxide dismutase in Adamantiades-Behçet's disease.
    Author: Wang LM, Kitteringham N, Mineshita S, Wang JZ, Nomura Y, Koike Y, Miyashita E.
    Journal: Arch Dermatol Res; 1997 Jul; 289(8):444-7. PubMed ID: 9266021.
    Abstract:
    Serum interleukin-8 (IL-8) production was measured in 43 Adamantiades-Behçet's disease (A-BD) patients and in 46 healthy volunteers using a sandwich enzyme-linked immunosorbent assay (ELISA). The mean serum IL-8 level of the patients (14.6 +/- 3 pg/ml) was significantly higher than that of controls (10.8 +/- 3 pg/ml, P < 0.05). Since IL-8 is known to have proinflammatory properties, it may play some role in the pathogenesis of A-BD. We also investigated the activity of serum superoxide dismutase (SOD) in the 43 patients with A-BD and in the 46 healthy volunteers. Serum SOD activity was markedly increased in the patients with A-BD (13.1 +/- 3%), especially in active A-BD, compared with that in the healthy volunteers (6.7 +/- 3%, P < 0.01). Our results suggest the involvement of IL-8 and SOD in the pathogenesis of A-BD as seen in other inflammatory diseases.
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