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  • Title: Epstein-Barr virus associated B-cell lymphoma after autologous bone marrow transplantation for T-cell acute lymphoblastic leukaemia.
    Author: Briz M, Forés R, Regidor C, Busto MJ, Ramon y Cajal S, Cabrera R, Díez JL, Sanjuán I, Fernández MN.
    Journal: Br J Haematol; 1997 Aug; 98(2):485-7. PubMed ID: 9266955.
    Abstract:
    Epstein-Barr virus associated lymphoproliferative disease after autologous bone marrow transplantation (ABMT) has rarely been reported. We report a case of B-cell lymphoma following ABMT for T-acute lymphoblastic leukaemia; bone marrow was purged in vitro with monoclonal antibodies to remove T cells. Immunoglobulin and T-cell receptor gene rearrangement studies were used to demonstrate clonality and to show that this patient developed a second neoplasm after ABMT. EBV proteins and genome (type A) were present in post-transplantation lymphoma, suggesting a causative role in its development.
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