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  • Title: Ultrastructural and immunocytochemical studies of prolactin-secreting cells in adenohypophysis of the mink (Mustela vison).
    Author: Vidal S, Lombardero M, Moya L.
    Journal: Gen Comp Endocrinol; 1997 Sep; 107(3):311-21. PubMed ID: 9268612.
    Abstract:
    This investigation aimed to identify, by the double immunogold procedure, the ultrastructural characteristics of prolactin (PRL) cells in the mink. Such cells showed a marked pleomorphism and had a close topographic relationship with growth hormone cells. A common morphological characteristic of PRL cells in all stages of mink development was the presence of round secretory granules, in contrast to changes in the ultrastructural characteristics of PRL cells with physiological state and photoperiod. Thus PRL cells in prepubertal, pubertal, and sexually inactive adult mink, killed under a short-day photoperiod, showed little development of the organelles but a significantly increased cytoplasmic electron density. In sexually active mink and in lactating females under long-day conditions, PRL cells had a highly developed cytoplasmic organelle structure consisting mainly of rough endoplasmic reticulum. The morphometric study demonstrated that the mean diameter of the secretory granules similarly varied in both sexes. Pubertal mink had PRL cells with smaller secretory granules (female 74.1 +/- 0.6 nm, male 80.4 +/- 1.7 nm), whereas adult mink killed under a long-day photoperiod presented PRL cells with larger secretory granules (female 194.5 +/- 2.2 nm, male 203.3 +/- 1.7 nm). The changes in the ultrastructural characteristics of PRL cells during the annual cycle suggest a photoperiodic influence upon these cells. In addition the heterogeneity in ultrastructural characteristics and storage characteristics of PRL in some adult mink may suggest a varying metabolic role for PRL under certain, as yet not fully characterized, conditions.
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