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  • Title: An ulcerated lesion at the BCG vaccination site during the course of Kawasaki disease.
    Author: Kuniyuki S, Asada M.
    Journal: J Am Acad Dermatol; 1997 Aug; 37(2 Pt 2):303-4. PubMed ID: 9270532.
    Abstract:
    We describe a bacillus Calmette-Guérin (BCG) granuloma that occurred during the course of Kawasaki disease. A 12-month-old male infant with Kawasaki disease had an erythematous indurated plaque with prominent necrotic ulceration at the BCG vaccination site on the left upper arm. Histologic study showed a granulomatous reaction consisting of epithelioid histiocytes, lymphoid cells, and Langhans-type giant cells. No evidence of mycobacterial infection was obtained. The lesion healed completely within 2 weeks without administration of antituberculous agents. We believe that the granulomatous reaction occurred as a result of hypersensitivity to proteins in the BCG vaccine, which appeared after the onset of Kawasaki disease.
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