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  • Title: [Comparison of the antitussive effect of two different drugs regarding frequency and strength of cough attacks (author's transl)].
    Author: Rühle KH, Gräber U, Matthys H.
    Journal: Med Klin; 1977 Nov 25; 72(47):2019-23. PubMed ID: 927305.
    Abstract:
    The antitussive effect of two different drugs A (Codeine, Phenyltoloxamine) and B (Dihydrocodeine, Remedacen) was compared in a double blind clinical trial by measuring the frequency and strength of cough attacks for 7 hours. The cough attacks were measured by a pressure-monitoring device which was externally fastened to the throat. Drug B suppressed the strenght and frequency for at least 9 hours after application while the effectiveness of drug A lasted only for about 6 hours after application. In any case the respiratory drive was unaffected.
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