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  • Title: [Effect of alpha-tocopherol and nuclear tocopherol-binding proteins on DNA-polymerase activity of isolated nuclei and nuclear matrix].
    Author: Donchenko GV, Petrova GV, Kapralov AA.
    Journal: Ukr Biokhim Zh (1978); 1996; 68(6):18-23. PubMed ID: 9273738.
    Abstract:
    It was shown, that tocopherol addition to the incubation medium increased the DNA-polymerase activity of isolated rat liver nuclei. This phenomenon was not discovered in nuclei of vitamin E-depleted rats. The action of tocopherol changed after the extraction of nuclei with triton X-100. In this situation tocopherol decreased DNA-polymerase activity of nuclei. The differences between rates of DNA synthesis was found after simultaneous addition of tocopherol and fraction of tocopherol-binding protein to the nuclei of normal and vitamin E-depleted rats. In this case DNA-polymerase activity of normal nuclei increased, but did not change in nuclei of vitamin E undernourished rats. The difference between them was about 30%. The differences between DNA-polymerase activity of normal and vitamin E-depleted rats after the addition of tocopherol and fraction of tocopherol-binding protein were also found in nuclear matrix preparation. It was supposed that tocopherol was able to take part in functioning of cell nuclei modulating DNA synthesis as well.
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