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  • Title: rhDNase in cystic fibrosis.
    Author: Conway SP, Littlewood JM.
    Journal: Br J Hosp Med; ; 57(8):371-2. PubMed ID: 9274660.
    Abstract:
    Cystic fibrosis (CF) affects approximately 1 in 2500 live births in the UK Caucasian population. Morbidity and mortality closely reflect the degree of pulmonary involvement. rhDNase is a new form of therapy in CF care. Phase 1, 2 and 3 trials have shown it to be well-tolerated, with patients showing initial increases in respiratory function of around 13% from baseline. A years prescription costs $7500. This review discusses our views on how this expensive new therapy can best be used.
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