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  • Title: Relationship between some humoral factors and left ventricular hypertrophy in essential hypertension.
    Author: Hui Y, Hao Y, Chen X, Jing S, Dai Z.
    Journal: Chin Med J (Engl); 1996 Nov; 109(11):885-7. PubMed ID: 9275376.
    Abstract:
    OBJECTIVE: To evaluate the relationship between certain humoral factors and left ventricular hypertrophy (LVH) in essential hypertension. PATIENTS AND METHODS: 62 essential hypertension (EH) patients (32 men, 30 women; mean age, 55 years) and 20 normotensive healthy subjects (10 men, 10 women: mean age, 52 years) were studied. EH patients were divided into LVH group and non-LVH group by echocardiography. After an overnight fast, blood samples were taken for the determination of parathyroid hormone (PTH), angiotensin II (ATII) and aldosterone (ALD) by radioimmunoassay. RESULTS: There was a significant difference in PTH. AT II and ALD between the EH group and control group. Furthermore, in LVH group PTH, ATII and ALD elevated significantly as compared with non-LVH group. In addition, we found that LVMI (left ventricular mass index) correlated with ATII (r = 0.342, P < 0.01) and ALD (r = 0.356, P < 0.01). There was a more significant correlation between LVMI and PTH (r = 0.422, P < 0.0025). CONCLUSIONS: Some humoral factors are important determinants of LV mass. Besides the reninangiotensin-aldosterone system, PTH might play an important role in cardiac hypertrophy.
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