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  • Title: [L-arginine nitric oxide pathway in acute renal ischemia reperfusion injury of the aged rats].
    Author: Chen A, Lu X, Wang H.
    Journal: Zhonghua Yi Xue Za Zhi; 1996 Aug; 76(8):572-7. PubMed ID: 9275467.
    Abstract:
    OBJECTIVE: To gain further insights into the greater susceptibility to acute ischemic renal injury (ARF, 45 minutes of renal arteries clamping) of old rats (O, 24-26 months) as against young ones (Y, 3-4 months), and the possible role of endothelium derived relaxing factor (EDRF) and its influence on ischemic renal function. METHODS: Basal renal dynamics was compared between O and Y. RESULTS: Two hours after ischemia, the decrease of GFR RPF, and UV was more severe in O than in Y. Urine cGMP was significantly dropped in both groups. Intravenous administration of L-arginine increasld urine cGMP of the O as well as the Y, with that of the Y higher than that in O. GFR, RPF, UV were elevated significantly in the O. Simultaneous administration of L-NNA, the analogue of L-Arginine could partially antagonize its effect on elevating RPF. RT-PCR technique was used to detect renal inducible nitric oxide synthase (iNOS) expression. Although the ischemic kidney was capable of expressing iNOS mRNA in the presence of L-arginine after ischemia, the production of NO in the old may not be regulated at the transcriptional level, other factors such as NOS enzyme activity, availability of L-arginine and O2, metabolism of NO after its production were suspected to be involved.
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