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  • Title: [Expression of thyrotropin receptor gene in autoimmune thyroid disease and the relation to expression of HLA genes].
    Author: Yang D, Gao Y, Li C.
    Journal: Zhonghua Yi Xue Za Zhi; 1996 Oct; 76(10):753-5. PubMed ID: 9275517.
    Abstract:
    OBJECTIVE: To investigate the expression of TSH receptor in autoimmune thyroid disease (AITD) and the relation to expression of HLA I and II genes. METHODS: The TSH receptor transcript levels were examined in 10 human thyroid fragments by Northern blot analysis. Graves' disease 7, Hashimoto's disease 2, and 1 healthy thyroid gland. RESULTS: TSH receptor transcript levels were higher in Graves' disease than in Hashimoto's disease and healthy control. CONCLUSION: TSH receptor expression was inversely related to HLA I and II expression and lymphocyte infiltration.
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