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  • Title: [The internalization of immunotargeting drugs for hepatocellar carcinoma and its significance].
    Author: Sui Y, Sun Z, Chen Z.
    Journal: Zhonghua Yi Xue Za Zhi; 1996 Nov; 76(11):845-7. PubMed ID: 9275537.
    Abstract:
    OBJECTIVE: To study the internalization law of immunotargeting drug for hepatocellular carcinoma and its significance. METHODS: Colloidal gold technique and the process of internalization of the immunotargeting drugs, Hab18-ADM and Hab25-ADM, against hepatoma in the targeting cells of human hepatoma cell line SMMC-7721 was used under an electron microscope. RESULTS: 80% of the target cells with gold-labeled particles on the cellular surfaces. The main way of internalization was invariably through a non-coated microinvagination. 18 hours after the intercellular internalization of immunotargeting drugs, the cytoplasmic vacuolization could be visible, even cellular necrosis. The control cells grew well. The above results indicate that after entering into the targeting cells the immunotargeting drugs degrade within the lysosomes, then, ADM arrives at its function site and plays the role of cell toxicity intranuclearly. CONCLUSION: The internalization of Hab 18-ADM and Hab25-ADM is effective, and possesses a good prospect in clinical application.
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