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  • Title: Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2.
    Author: Chance WT, Foley-Nelson T, Thomas I, Balasubramaniam A.
    Journal: Am J Physiol; 1997 Aug; 273(2 Pt 1):G559-63. PubMed ID: 9277438.
    Abstract:
    Maintaining rats on total parenteral nutrition (TPN) for 6 days significantly reduced mass (-34%), protein (-32%), and DNA (-35%) in small intestine and colon (29-37% decrease). Coinfusion of glucagon-like peptide-2 (GLP-2) normalized each of these variables in duodenum, jejunum, and ileum, but not in colon. Histological analysis of tissue revealed normal mucosa thickness and villus height in small intestine of GLP-2-treated rats, whereas nontreated rats maintained on TPN exhibited villus shortening (-30%) and thinning (-23%) of mucosa. These results suggest that hormonal alterations may be more important than an absence of luminal nutrition in TPN-associated mucosal changes. Additionally, GLP-2 normalization of gut mucosa permits accurate assessment of the influence of reversal of hypoplasia on gut barrier function.
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