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  • Title: Synovial sarcoma of the head and neck: chromosomal translation (X;18) as a diagnostic aid.
    Author: Cihak RA, Lydiatt WM, Lydiatt DD, Bridge JA.
    Journal: Head Neck; 1997 Sep; 19(6):549-53. PubMed ID: 9278765.
    Abstract:
    BACKGROUND: Synovial sarcoma, a rare tumor in the head and neck, has been historically diagnosed by its characteristic biphasic histologic pattern. Monophasic variants exist which can be difficult to diagnose. METHODS: Two cases of synovial sarcoma of the head and neck are presented. Both cases, cytogenetic analysis was performed using standard protocols. RESULTS: Both tumors demonstrated a chromosomal translocation, t(X;18)(p11.2;q11.2), which either made or confirmed the diagnosis. CONCLUSIONS: Synovial sarcoma contains a characteristic chromosomal translocation which is a useful diagnostic tool, especially when histologic studies are equivocal.
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