These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Critical levels of spinal cord blood flow and duration of ischemia for the acute recovery of segmental spinal cord responses in cats.
    Author: Kolenda H, Steffens H, Gefeller O, Hagenah J, Schomburg ED.
    Journal: J Spinal Disord; 1997 Aug; 10(4):288-95. PubMed ID: 9278912.
    Abstract:
    A broad range of residual lumbar spinal cord blood flows assessed by laser-Doppler flowmetry (rSCBF, 0-78%) was achieved by snare occlusion of the descending aorta and additional blood-volume reduction for 1-10 min in spinal cats (n = 30; 238 trials). The period of complete reflex suppression (delay until recovery) that revealed some correlation to duration (r = 0.72) and depth (r = -0.36) of ischemia showed comparable durations in mono- and polysynaptic reflexes, whereas it was significantly less for the cord dorsum potential (CDP). With rSCBF values > 50-60% reflexes and > 45%, the CDP was rarely abolished, irrespective of the duration of ischemia. The threshold of duration for a complete loss of reflex responses was found to be approximately 1 min of ischemia. The influence of rSCBF and duration of ischemia on the occurrence of incomplete recoveries of reflexes was assessed simultaneously in a logistic regression model. Compared with periods of ischemia of 3 min, all longer durations showed a steep risk gradient for incomplete recoveries; an increment of 10% in rSCBF led to a risk reduction for incomplete recoveries of nearly 25%. These findings were significant (p < 0.001) and indicated that blood-flow thresholds and limits for the development of neurologic deficits of the spinal cord are comparable to those of the brain, with the important difference that the blood-flow reserve of the spinal cord is smaller.
    [Abstract] [Full Text] [Related] [New Search]