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  • Title: Abnormal plasma oxytocin and beta-endorphin levels in alcoholics after short and long term abstinence.
    Author: Marchesi C, Chiodera P, Brusamonti E, Volpi R, Coiro V.
    Journal: Prog Neuropsychopharmacol Biol Psychiatry; 1997 Jul; 21(5):797-807. PubMed ID: 9278951.
    Abstract:
    1. Plasma oxytocin (OX), vasopressin (VP), estrone (ES) and beta-endorphin (beta-end) levels were measured in 13 male non-chirrotic alcoholics, at 1, 4, 7, 15 and 28 days after alcohol withdrawal and only once in 9 sex- and age-matched normal controls. 2. At all examined time points, plasma OX and ES, but not VP, levels were significantly higher in alcoholics than in controls. Alcoholics showed plasma beta-end levels lower than normal. 3. A positive relationship was found between ES and OX levels suggesting that elevated estrogens levels in chronic alcoholics might exert a stimulatory effect on OX. 4. In light of the well-known effect of OX on learning and memory, an involvement of OX in alcohol-induced neuropsychological deficits may be supposed.
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