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  • Title: Bronchiolitis obliterans and IgA nephropathy. A new cause of pulmonary-renal syndrome.
    Author: Hernández JI, Gómez-Román J, Rodrigo E, Olmos JM, González-Vela C, Ruiz JC, Val JF, Riancho JA.
    Journal: Am J Respir Crit Care Med; 1997 Aug; 156(2 Pt 1):665-8. PubMed ID: 9279256.
    Abstract:
    IgA nephropathy is a common form of glomerulonephritis, classically manifested by asymptomatic hematuria. Although the exact pathophysiologic mechanism is still unknown, renal damage has been related to mesangial deposition of IgA-containing immune complexes. In recent years, some lung diseases have been associated with IgA nephropathy, including pulmonary hemorrhage and sarcoidosis. We report a patient with idiopathic bronchiolitis obliterans who developed a rapidly progressive glomerulonephritis due to IgA deposits. Extensive deposits of IgA were also found in the lungs, thus suggesting a pathogenetic role for IgA in tissue injury at both organ levels. To our knowledge this association has not been previously described in the literature.
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