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  • Title: Immunological interactions between Trichinella spiralis and Heligmosomoides polygyrus: cross reactivity between muscle larvae and antibodies raised to unrelated antigens.
    Author: Robinson M, Gustad TR, Erickson MR.
    Journal: Int J Parasitol; 1997 Jul; 27(7):865-72. PubMed ID: 9279592.
    Abstract:
    It is documented that concurrent infections in mice with the 2 unrelated nematode parasites, Heligmosomoides polygyrus and Trichinella spiralis, can result in delayed rejection of the latter species. The basis of this immunological interference is not completely understood, but a possibility exists that antibodies induced by 1 species may interact with antigens produced by the other parasite. Therefore, it was investigated whether H. polygyrus infections may induce the production of antibodies which could cross react with T. spiralis muscle larval (m.l.) antigens. The results shown here indicate that this assumption is correct, and there is cross reactivity between antibodies produced against H. polygyrus, and T. spiralis m.l. antigens. Furthermore, antibodies which were not specific for either species were also able to bind to T. spiralis m.l. This is in agreement with recent evidence which has shown that antibodies that are not specific for H. polygyrus may still be absorbed by an H. polygyrus homogenate. It is considered that the binding of these antibodies may be involved in manipulation of the host immune response by T. spiralis.
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