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  • Title: Acute effects of tetrahydrobiopterin on the dynamic characteristics and adaptability of of vestibulo-ocular reflex in normal and flocculus lesioned rabbits.
    Author: Nagao S, Kitazawa H, Osanai R, Hiramatsu T.
    Journal: Neurosci Lett; 1997 Aug 01; 231(1):41-4. PubMed ID: 9280163.
    Abstract:
    The acute effects of (6R)-5,6,7,8-tetrahydro-L-biopterin (R-THBP) on the dynamic characteristics of horizontal vestibulo-ocular reflex (HVOR) were examined in chronically prepared alert pigmented rabbits. The HVOR gain was measured by 10 degrees-0.1 Hz sinusoidal oscillation of the turntable in darkness. In control rabbits, intramuscular injection of R-THBP (10 mg/kg) induced an increase of HVOR gain by 0.1-0.2, which lasted for 1-3 h. Sustained 10 degrees-0.1 Hz sinusoidal oscillation of the turntable and screen in the reversed direction induced an adaptive increase of HVOR gain by 0.2 in 3 h, which was not affected by applications of R-THBP. In flocculus lesioned rabbits, the HVOR gain reduced by 23%, and applications of R-THBP no longer induced a HVOR gain increase. These experimental observations suggested that the R-THBP affected on the HVOR dynamics within the cerebellar flocculus or its related neural areas.
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