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  • Title: [Neurological manifestations of Paget's disease: presentation of one case and review of the literature].
    Author: Meca JE, Moltó-Jordà JM, Morales-Ortiz A, Martínez-García FA, Ruiz-Barnés P, Fernández-Barreiro A.
    Journal: Rev Neurol; 1997 Jul; 25(143):1076-8. PubMed ID: 9280638.
    Abstract:
    INTRODUCTION: Paget's disease is a frequent metabolic disease. It is usually diagnosed as a accidental finding. Initial symptoms usually consist of generalized pain in bones. When it affects the Central Nervous System, symptoms usually appear in advanced cases and are due mainly to compression of the spinal cord. Neurological problems as the first manifestation of the disease are exceptionally found. CLINICAL CASE: We report the case of a woman affected by Paget's disease who presented as a triventricular obstructive hydrocephalus. The patient was 72 years old and consulted first to the emergency ward due to headache, gait disorders and cognitive abnormalities. COMMENTS: The most remarkable data about this patient are the indolent course of the disease which caused its debut as hydrocephalus associated to basilar impression, its favourable evolution after ventricular drainage and the almost absolute absence of previous similar cases reported in literature all over the last years.
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