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  • Title: Effect of age on P300 wave.
    Author: Jha S, Shukla R, Nag D, Kar AM, Agarwal A.
    Journal: J Assoc Physicians India; 1995 Jan; 43(1):21-3. PubMed ID: 9282633.
    Abstract:
    30 healthy elderly males (mean age 77.4 +/- 4.3 yrs) were subjects in this study. Equal number of young males (mean age 22 +/- 3.5 years) and middle aged subjects (mean age 46 +/- 3.2 years) served as control. P300 wave was estimated using a Neuropack 4 model of Nihon Kohden EMG machine. We observed a significantly increased latency, poorly defined and non reproducible P300 wave in 90% old subjects while in young the latency was in normal limits and the wave was well defined and reproducible. We presume P300 could serve as a future potential marker of the neurophysiological basis of aging.
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