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  • Title: Allelic variation in Streptococcus pneumoniae autolysin (N-acetyl muramoyl-L-alanine amidase).
    Author: Gillespie SH, McHugh TD, Ayres H, Dickens A, Efstratiou A, Whiting GC.
    Journal: Infect Immun; 1997 Sep; 65(9):3936-8. PubMed ID: 9284174.
    Abstract:
    The lytA gene encoding the autolysin of Streptococcus pneumoniae may be a virulence determinant. Single-strand conformational polymorphism analysis demonstrated heterogenicity throughout the gene in clinical isolates and strains from the clonal serotypes 7 and 14. Sequence analysis of part of the choline-binding domain showed that in two isolates four amino acid substitutions occurred.
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