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  • Title: A human monoclonal antibody which inhibits the coaggregation activity of Porphyromonas gingivalis.
    Author: Abiko Y, Ogura N, Matsuda U, Yanagi K, Takiguchi H.
    Journal: Infect Immun; 1997 Sep; 65(9):3966-9. PubMed ID: 9284182.
    Abstract:
    A B-cell line producing a human monoclonal antibody (HuMAb) against a recombinant 40-kDa outer membrane protein (OMP) of Porphyromonas gingivalis was constructed by in vivo immunization of a severe combined immunodeficiency C.B.-17/Icr mouse, which had been injected with human peripheral blood lymphocytes, with recombinant 40-kDa OMP and subsequent Epstein-Barr virus immortalization of B cells isolated from the spleen of the mouse. This HuMAb inhibited coaggregation between P. gingivalis vesicles and Actinomyces naeslundii cells.
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