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  • Title: Angiotensin II antagonism: a new avenue of hypertension management.
    Author: Gavras H.
    Journal: Blood Press Suppl; 1997; 1():42-6. PubMed ID: 9285108.
    Abstract:
    Receptor-level blockade of angiotensin II (AII) has emerged as a new therapeutic principle in cardiovascular medicine. Experience with losartan, the first of the selective AII receptor antagonists to be approved for clinical use, indicates that this approach is efficacious in all grades of hypertension and offers a more attractive and acceptable tolerability profile than other forms of antihypertensive medications. Recent clinical trial data indicate that losartan may also be beneficial in heart failure in older patients, though the drug is not yet approved for this indication.
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