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  • Title: Unsuccessful CTL transfusion in a case of post-BMT Epstein-Barr virus-associated lymphoproliferative disorder (EBV-LPD).
    Author: Imashuku S, Goto T, Matsumura T, Naya M, Yamori M, Hojo M, Hibi S, Todo S.
    Journal: Bone Marrow Transplant; 1997 Aug; 20(4):337-40. PubMed ID: 9285550.
    Abstract:
    A patient with AML (FAB M4Eo) developed EBV-LPD 1.5 months after allogeneic BMT from his one locus-mismatched mother, the diagnosis being confirmed on day +82. Attempts to eradicate the monoclonally proliferating LPD using chemotherapy (VP16/dexamethasone) followed by two doses of EBV-specific CTL and one dose of unstimulated donor leukocytes were not successful. We assume delay of infusions (day +100, +107) and insufficient CTL cell doses (total 9.2 x 10(6)) may have been responsible for the poor outcome in this case.
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