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  • Title: [The presence of Human Papillomavirus (HPV) in microinvasive in situ spinocellular carcinoma of the oral cavity. Preliminary report].
    Author: Mignogna MD, Duraccio R, Carbone R, Mignogna RE, Lo Muzio L.
    Journal: Minerva Stomatol; 1997 Jun; 46(6):287-91. PubMed ID: 9289629.
    Abstract:
    BACKGROUND: The authors examined 15 cases of in situ and early oral SCC to detect the presence of HPV genoma. METHODS: They proceeded to in situ hybridization on paraffined specimens utilizing DNA-biotinylated fragments in commercial kit (Vyra Type in situ, Life Technologies, Gaithersburg, MD, USA). RESULTS: HPV-DNA was detected in 9 cases: 6/11, 16/18, 31/33/35 serotypes were detected. The distribution of viral serotypes by sites showed a prevalence of 16/18 serotype in tongue and floor of the mouth carcinoma, a prevalence of 6/11 serotype in gingiva, hard palate and buccal mucosa carcinoma, and 31/33/35 in commissura. CONCLUSIONS: The results suggest an important role of HPV in oral carcinogenesis, but further investigations are necessary to confirm these data on larger groups of patients to obtain a higher significance of the results.
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