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  • Title: T-cell sensitization to epitopes from the house dust mites Dermatophagoides pteronyssinus and Euroglyphus maynei.
    Author: Hales BJ, Thomas WR.
    Journal: Clin Exp Allergy; 1997 Aug; 27(8):868-75. PubMed ID: 9291282.
    Abstract:
    BACKGROUND: Dermatophagoides pteronyssinus and Euroglyphus maynei frequently occur in house dust but little is known about primary sensitization to the less abundant E. maynei. OBJECTIVE: To determine the occurrence of primary sensitization to E. maynei by T-cell responses and the crossreactivity to D. pteronyssinus. METHODS: The proliferative response of peripheral blood cells to overlapping peptides from Der p 1 and Eur m 1 were measured as well as to peptides from Der f 1, an allergen not found in the study environment. RESULTS: The most frequent and strongest responses were to Der p 1 peptides especially in the region 105-133. However, 3/17 responders to mite peptides were stimulated predominantly by Eur m 1 peptides and a further two had their highest response to an Eur m 1 peptide. There was very little crossreactivity between Der p 1 and Eur m 1 peptides and very little response to peptides from Der f 1. CONCLUSION: E. maynei group 1 allergens are a significant source of primary T-cell sensitization and have little T-cell crossreactivity with D. pteronyssinus or D. farinae.
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