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  • Title: Bcl-2 and p53 protein expression in aortic, mammary artery and saphenous vein biopsies in patients subjected to open heart surgery.
    Author: Aaltomaa S, Hippeläinen M, Lipponen P.
    Journal: In Vivo; 1997; 11(4):337-43. PubMed ID: 9292301.
    Abstract:
    BACKGROUND: Stenosis of vascular grafts is a common phenomenon after coronary by-pass surgery and factors favoring stenosis are incompletely understood. The present study is a prospective clinicopathological study on the relationship between factors controlling cell proliferation (p53) and programmed cell death (bcl-2) in patients suffering from atherosclerotic heart diseases. MATERIALS: The expression of p53 and bcl-2 proteins was analyzed in samples obtained from the aortic wall, internal mammary artery, and saphenous veins in 96 patients subjected to open heart surgery. METHODS: The expression of p53 and bcl-2 proteins in vascular channel intima and media was analyzed by immunohistochemistry. RESULTS: The expression of bcl-2 was more common in males than in females (p = 0.05). The expression of bcl-2 was significantly more common (p = 0.004) in venous intima in patients with insulin-dependent diabetes than in patients with non-insulin dependent diabetes or with no diabetes. Expression of p53 was related to insulin-dependent diabetes in venous intima with a borderline significance (p = 0.08). CONCLUSIONS: The results show that bcl-2 and p53 are expressed in vessel walls and may be related to potential risk of stenosis of vascular grafts particularly in patients with insulin-dependent diabetes mellitus.
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