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  • Title: [A childhood case of systemic lupus erythematosus associated with myasthenia gravis].
    Author: Nishimura A, Yamazaki H, Fuchigami T, Fujita Y, Okubo O, Harada K, Harasawa T.
    Journal: No To Hattatsu; 1997 Sep; 29(5):390-5. PubMed ID: 9294315.
    Abstract:
    We described a 12-year-old girl with systemic lupus erythematosus (SLE) associated with myasthenia gravis (MG). She had absence seizures from 6 years old. She admitted to our hospital at 12 years of age because of absence seizures and dyspnea. The diagnosis of SLE was made on the basis of convulsion, arthritis, pleurisy, and positive antinuclear factor and was started therapy with prednisolone. The clinical course was complicated by the appearance of dysphagia and hoarseness. On the basis of positive Tensilon test and a high level of serum anti-acetylcholine receptor antibody, we made a diagnosis of the systemic type of MG. Her condition was improved by methylprednisolone pulse therapy and gamma-globulin therapy after plasmapheresis. The association of early-onset SLE with MG is rare.
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