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  • Title: CO interact with intracellular [H+] with and without CO2-HCO3- in the cat carotid chemosensory discharge.
    Author: Osanai S, Rozanov C, Mokashi A, Buerk DG, Lahiri S.
    Journal: Brain Res; 1997 Aug 01; 764(1-2):221-4. PubMed ID: 9295213.
    Abstract:
    To test the hypothesis whether CO2-HCO3- buffer is essential for the expression of chemoreception and to distinguish between pHi and pHo interaction with pCO in the carotid chemosensory response, we superfused-perfused in vitro cat carotid bodies using HEPES-Tyrode's solution with and without CO2-HCO3-, and compared the responses at the same pHo in the absence and presence of light. In the absence of light, pCO (> 138 Torr) stimulated the carotid body chemoreceptors in CO2-HCO3- buffer at pHo of 7.40, whereas pCO (69-550 Torr) did not stimulate the neural discharge in HEPES buffer at the pHo of 7.4-7.1 but did so below pHo 7.1. In the presence of light, all the responses were diminished proportionately.
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