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  • Title: 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis.
    Author: Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S.
    Journal: Science; 1997 Sep 19; 277(5333):1827-30. PubMed ID: 9295274.
    Abstract:
    Renal 25-hydroxyvitamin D3 1alpha-hydroxylase [1alpha(OH)ase] catalyzes metabolic activation of 25-hydroxyvitamin D3 into 1alpha, 25-dihydroxyvitamin D3 [1alpha,25(OH)2D3], an active form of vitamin D, and is inhibited by 1alpha,25(OH)2D3. 1alpha(OH)ase, which was cloned from the kidney of mice lacking the vitamin D receptor (VDR-/- mice), is a member of the P450 family of enzymes (P450VD1alpha). Expression of 1alpha(OH)ase was suppressed by 1alpha, 25(OH)2D3 in VDR+/+ and VDR+/- mice but not in VDR-/- mice. These results indicate that the negative feedback regulation of active vitamin D synthesis is mediated by 1alpha(OH)ase through liganded VDR.
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