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  • Title: [The significance of gender incompatibility in donors and recipients and the role of minor histocompatibility antigens in corneal transplantation].
    Author: Hasková Z, Filipec M, Holán V.
    Journal: Cesk Slov Oftalmol; 1997 May; 53(2):128-35. PubMed ID: 9296861.
    Abstract:
    AIM: The present study evaluates the ability of single male H-Y antigen to elicit corneal graft rejection or to prime recipient with subsequent induction of second-set corneal graft rejection in mice. Results were compared with the survival rates of orthotopic corneal grafts disparate at multiple minor histocompatibility (H) antigens and with syngeneic grafts. METHODS: A/Ph male or B10.A female and A/Ph female corneas were grafted onto A/Ph female mice. During the fourth week after grafting all acceptors of H-Y disparate grafts received the second corneal graft from the same donor. All grafts were evaluated three times a week during the period of nine weeks. RESULTS: Both first and second orthotopic corneal grafts incompatible at H-Y antigen did not display and sign of rejection reaction during the whole observation period and were accepted indefinitely. The rate of rejection reaction of grafts incompatible at multiple minor H antigens was 83%. Thirty-three percent of these grafts underwent rejection irreversibly. CONCLUSIONS: Single H-Y antigen disparity between corneal graft donor and recipient neither led to rejection of first grafts nor primed recipients as shown by tolerance of 100% of second-set grafts. Experiments demonstrated that incompatibility of sex between donor and recipient does not play role in corneal graft rejection. However, incompatibility at multiple minor H antigens led to the rejection reaction in 83% of first grafts and 33% of these grafts failed.
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