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  • Title: Chondrosarcoma as a complicating factor in Paget's disease of bone.
    Author: Brandolini F, Bacchini P, Moscato M, Bertoni F.
    Journal: Skeletal Radiol; 1997 Aug; 26(8):497-500. PubMed ID: 9297756.
    Abstract:
    A 65-year-old male patient with an 8-year history of poliostotic Paget's disease complained of shoulder pain that started 6 months prior to admission. An extensive lytic area was identified in the right proximal humerus along with Paget's disease. There was cortical destruction and a soft tissue mass. Following an incisional biopsy, a diagnosis of grade 2 chondrosarcoma associated with Paget's disease was made. The histologic identification of chondrosarcoma associated with Paget's disease is rare. However, the presence of a calcified matrix in a destructive lesion associated with Paget's disease should alert the radiologist and the pathologist to the possibility of a chondromatous differentiation taking place in the sarcoma associated with Paget's disease. The histologic evaluation of the lesion will form the basis for the diagnosis.
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