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  • Title: Rel/NF-kappa B and I kappa B proteins: an overview.
    Author: May MJ, Ghosh S.
    Journal: Semin Cancer Biol; 1997 Apr; 8(2):63-73. PubMed ID: 9299584.
    Abstract:
    Rel/NF-kappa B proteins constitute a family of structurally-related transcription factors that are regulated by interaction with a family of regulatory proteins, the I kappa B proteins. In this review, we will familiarize the reader with the known Rel/NF-kappa B and I kappa B molecules, and will discuss the types of interactions that occur between these proteins to regulate their function. In addition, we will describe what is known about the structure of Rel/NF-kappa B transcription complexes on DNA. Lastly, we will discuss the wide variety of biological stimuli and conditions which activate NF-kappa B and the genes whose expression are regulated by this family of transcription factors.
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