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  • Title: The paired-pulse index: a measure of hippocampal dentate granule cell modulation.
    Author: Bronzino JD, Blaise JH, Morgane PJ.
    Journal: Ann Biomed Eng; 1997; 25(5):870-3. PubMed ID: 9300111.
    Abstract:
    This study was undertaken to assess whether the paired-pulse index (PPI) is an effective measure of the modulation of dentate granule cell excitability during normal development. Paired-pulse stimulations of the perforant path were, therefore, used to construct a PPI for 15-, 30-, and 90-day old, freely moving male rats. Significant age-dependent differences in the PPI were obtained. Fifteen-day old rats showed significantly less inhibition at short interpulse intervals [interpulse interval (IPI): 20 to 30 msec), a lack of facilitation at intermediate IPIs (50 to 150 msec), and significantly less inhibition at longer IPIs (300 to 1,000 msec) than adults.
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