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  • Title: [Platelet transfusion refractoriness and effective management of platelet alloimmunization].
    Author: Amemiya Y.
    Journal: Nihon Rinsho; 1997 Sep; 55(9):2392-8. PubMed ID: 9301306.
    Abstract:
    Platelet transfusion recipients become alloimmunized to foreign HLA and HPA antigens, impairing their responses to further platelet transfusions (platelet transfusion refractoriness; PTR). Anti-HLA and HPA antibodies account for the majority of clinically significant alloimmunizations. Poor transfusion responses due to alloimmunization may be overcome by selection of HLA or HPA-compatible donors. Several approaches including use of white cell-depleted products have been shown to prevent or delay alloimmunization in transfusion recipients. This paper focused on: 1) factors involved in the development of platelet alloimmunization, 2) diagnosis of PTR and platelet alloimmunization, 3) effective management of the alloimmunization.
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