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  • Title: Effect of stanozolol on body composition, nitrogen balance, and food consumption in castrated dogs with chronic renal failure.
    Author: Cowan LA, McLaughlin R, Toll PW, Brown SA, Moore TI, Butine MD, Milliken G.
    Journal: J Am Vet Med Assoc; 1997 Sep 15; 211(6):719-22. PubMed ID: 9301741.
    Abstract:
    OBJECTIVE: To determine the effect of stanozolol on body composition, nitrogen balance, and food consumption in castrated dogs with chronic renal failure. DESIGN: Blinded crossover trial. ANIMALS: 22 castrated Beagles with experimentally induced chronic renal failure. PROCEDURE: Dogs were divided into 2 groups of 11 dogs each. During each of two 6-week treatment periods, dogs in 1 group received stanozolol, and those in the other group received a control agent. Nitrogen balance, body composition, and food consumption were determined. RESULTS: During administration of stanozolol, the amount of food consumed per dog, lean body mass, and nitrogen balance increased. Stanozolol did not have a significant effect on body fat, bone mineral content, or food consumption per kilogram of body weight. CLINICAL IMPLICATIONS: For dogs with mild-to-moderate, nonuremic, experimentally induced, chronic renal failure, stanozolol had positive effects on nitrogen balance and lean body mass.
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