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  • Title: Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras.
    Author: Ahmadian MR, Stege P, Scheffzek K, Wittinghofer A.
    Journal: Nat Struct Biol; 1997 Sep; 4(9):686-9. PubMed ID: 9302992.
    Abstract:
    RasGAPs supply a catalytic residue, termed the arginine finger,into the active site of Ras thereby stabilizing the transition state of the GTPase reaction and increasing the reaction rate by more than one thousand-fold, in good agreement with the structure of the Ras.RasGAP complex.
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