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  • Title: Reconstitution of the protein insertion machinery of the mitochondrial inner membrane.
    Author: Haucke V, Schatz G.
    Journal: EMBO J; 1997 Aug 01; 16(15):4560-7. PubMed ID: 9303300.
    Abstract:
    We have reconstituted the protein insertion machinery of the yeast mitochondrial inner membrane into proteoliposomes. The reconstituted proteoliposomes have a distinct morphology and protein composition and correctly insert the ADP/ATP carrier (AAC) and Tim23p, two multi-spanning integral proteins of the mitochondrial inner membrane. The reconstituted system requires a membrane potential, but not Tim44p or mhsp70, both of which are required for the ATP-driven translocation of proteins into the matrix. The protein insertion machinery can thus operate independently of the energy-transducing Tim44p-mhsp70 complex.
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