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  • Title: Penicillin-binding proteins and induction of AmpC beta-lactamase.
    Author: Sanders CC, Bradford PA, Ehrhardt AF, Bush K, Young KD, Henderson TA, Sanders WE.
    Journal: Antimicrob Agents Chemother; 1997 Sep; 41(9):2013-5. PubMed ID: 9303404.
    Abstract:
    In competition assays for radiolabeled penicillin, penicillin-binding proteins (PBPs) 4, 7a, and 7b showed very high affinities for strong inducers of AmpC beta-lactamase. Loss of PBP 4 resulted in diminished inducibility. This suggests that if PBPs are involved in induction of AmpC beta-lactamase, there is probably a redundancy in function among the different PBPs.
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