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  • Title: HLA-DQA1 and polymarker allele frequencies in two New York City Jewish populations.
    Author: Medintz I, Levine L, McCurdy L, Chiriboga L, Kingston C, Crim D, Desnick RJ, Eng CM, Kobilinsky L.
    Journal: J Forensic Sci; 1997 Sep; 42(5):919-22. PubMed ID: 9304843.
    Abstract:
    Allele and genotype frequencies were determined for the HLA-DQA1 and Amplitype Polymarker loci (low density lipoprotein receptor (LDLR), glycophorin A (GYPA), hemoglobin G gammaglobin (HBGG), D7S8, and group-specific component (Gc)) in Hasidic and non-Hasidic Ashkenazi New York City Jewish subpopulations. For all loci tested, except HBGG, the 2 subpopulations meet the assumption of Hardy-Weinberg equilibrium. Comparison of various allele and genotype frequencies for the Hasidic and the non-Hasidic groups showed no significant differences. Comparison of the various allele frequencies in the two subpopulations to another Caucasian group revealed significant differences at the HLA-DQA1 and D7S8 loci in the Hasidic group. These frequency data can be used for comparison to other populations and for frequency estimates in DNA profiling.
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