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  • Title: [Clinical manifestations of disseminated sclerosis in childhood].
    Author: Lachkepiani AN.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1977; 77(10):1523-7. PubMed ID: 930501.
    Abstract:
    The author studied children from 6-14 years with disseminated sclerosis in the area of a decreased risk to this disease. The early period of the disease in this age group was very difficult to discern. As a rule, disseminated sclerosis in children in detected by a retrospective analysis of the clinical development. In children, as in adults, the clinical course has a remittent development, where there are remissions and exacerbations. More frequently than in adults, the disease acquires a hyperkinetic form, which is considered to be most malignant. Probably the disease occurs not at 12-15 years, as it is being pointed in the literature but much earlier (4-5 years). Exacerbations of disseminated sclerosis in children, unlike exacerbations in adults occur not so much from the influence of cold factors as from warm. In order to avoid a hyperdiagnosis of disseminated sclerosis in children a differential diagnosis should be made between hereditary-degenerative disorders of the nervous system and progressive forms of panencephalitis.
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