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  • Title: Malignant potential of oral lichen planus; a follow-up study of 326 patients.
    Author: Markopoulos AK, Antoniades D, Papanayotou P, Trigonidis G.
    Journal: Oral Oncol; 1997 Jul; 33(4):263-9. PubMed ID: 9307716.
    Abstract:
    326 patients with oral lichen planus were followed for periods ranging from 6 months to 10 years (mean 4.8 years), in an attempt to clarify the malignant potential of this disease which is still controversial. Malignant transformation occurred in 4 patients (1.3%) in a mean time of 6.5 years after the onset of lichen planus. Before cancer development, 3 of these patients manifested the erosive form of oral lichen planus, while the others, a combination of the papular/atrophic form. Malignant transformation in our patients could not be associated with any evident factors, such as family history, local irritation, alcohol consumption, nutritional disturbances or other systemic diseases.
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