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  • Title: [Sensitivity to fosfomycin of multiresistant serotype 012 Pseudomonas aeruginosa. Multicenter study].
    Author: Dubrous P, Cavallo JD, Buisson Y.
    Journal: Pathol Biol (Paris); 1997 Jun; 45(6):472-8. PubMed ID: 9309262.
    Abstract:
    In a multicentric study including 214 strains of Pseudomonas aeruginosa, we observed that serotype O12 is more frequently sensitive to fosfomycine than other serotypes strains (72% vs 13.2%, p < 0.000001). Time killing experiments demonstrated that combination of ceftazidime-fosfomycine and amikacine-fosfomycine have usually bactericidal and synergistic activities and could be used for the treatment of multiresistant Pa O12 infections. However, an antagonism between beta-lactams and fosfomycin in disk diffusion needs an adequate concentration of both antibiotics in the site of infection.
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