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  • Title: In vitro plasmid-encoded resistance to quinolones.
    Author: Gómez-Gómez JM, Blázquez J, Espinosa De Los Monteros LE, Baquero MR, Baquero F, Martínez JL.
    Journal: FEMS Microbiol Lett; 1997 Sep 15; 154(2):271-6. PubMed ID: 9311124.
    Abstract:
    The possibility of plasmid-encoded quinolone resistance is explored in two model systems. In the first, increasing amounts of wild-type gyrA allele moderately increased minimum inhibitory concentrations to quinolone antibiotics. In the second model, a mutant gyrA allele encoded by a multicopy plasmid produced a quinolone resistance phenotype upon its expression in a quinolone-susceptible Escherichia coli strain.
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