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  • Title: Hemodynamic effects of acute hypoxia and minute amounts of endotoxin in awake swine.
    Author: Orr JA, Ungerer T, Bisgard GE, Will JA.
    Journal: Am J Vet Res; 1977 Nov; 38(11):1753-6. PubMed ID: 931159.
    Abstract:
    Hemodynamic measurements and arterial blood gases were determined from awake swine (n = 8) during acute hypoxia (12% O2, balance N2 for 5 minutes) and following injection of Escherichia coli endotoxin (4 microgram/kg of body weight) into the pulmonary artery. Comparison of baseline data with these treatments indicated: (1) swine exhibited a marked pulmonary pressor response to acute hypoxia (deltaBPpul = 9 to 12 mm of Hg): (2) injection of minute amounts of endotoxin led to a marked increase of pulmonary arterial blood pressure 10 to 20 minutes following the injection (deltaBPpul = 15 mm of Hg); and (3) the pulmonary pressor response to a 2nd exposure of acute hypoxia was unaffected by the intervening endotoxin injection.
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