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  • Title: The influence of atenolol and propafenone on QT interval dispersion in patients 3 months after myocardial infarction.
    Author: Puljevic D, Smalcelj A, Durakovic Z, Goldner V.
    Journal: Int J Clin Pharmacol Ther; 1997 Sep; 35(9):381-4. PubMed ID: 9314091.
    Abstract:
    UNLABELLED: The aim of the study was to determine changes in QTc dispersion and QTc interval during the administration of atenolol and propafenone. METHODS: Eighty-five patients, 3 months after myocardial infarction, were randomized in 2 groups. The first group (n = 46) received atenolol 50 mg daily during 7 days and the second group (n = 39) propafenone 300 mg per os twice a day. QT interval was measured in 12 ECG leads before and after the treatment after 100% strip enlargement on a photocopy machine. For correction we used Bazett's formula. QTc dispersion was defined as the difference between the longest and the shortest QTc interval in 12 ECG leads. RESULTS: QTc dispersion increased significantly with the severity of arrhythmia (< 50 premature ventricular complexes vs. ventricular tachycardia, 82.3 (18.1) vs. 110.0 (9.0) ms (p < 0.001)). QTc dispersion significantly decreases with the administration of atenolol (72.7 (14.8) vs. 63.6 (15.3)) (p < 0.001) as well as with propafenone (75.0 (17.7) vs. 63.2 (16.4)) (p < 0.001). QTc interval also decreases with atenolol (451 (28) vs. 431 (32)) (p < 0.01) while it does not change with propafenone administration (441 (26) vs. 444 (26)). CONCLUSION: QTc dispersion is associated with ventricular tachycardia. Both atenolol and propafenone significantly decrease QTc dispersion. Atenolol also decreases QTc interval, while with propafenone it does not change.
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