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  • Title: Intravenous cyclosporine therapy in the treatment of pyoderma gangrenosum secondary to Crohn's disease.
    Author: Carp JM, Onuma E, Das K, Gottlieb AB.
    Journal: Cutis; 1997 Sep; 60(3):135-8. PubMed ID: 9314617.
    Abstract:
    Pyoderma gangrenosum is a destructive, ulcerative skin condition often associated with systemic illnesses such as inflammatory bowel disease, myeloproliferative disorders, and the inflammatory arthritides. We present a patient with long-standing pyoderma gangrenosum associated with Crohn's disease. Multiple deep leg ulcerations were unresponsive over the course of several years to treatment with azathioprine, systemic corticosteroids, 6-mercaptopurine, and dapsone. The patient was hospitalized and treated with a ten-day course of intravenous cyclosporine therapy followed by outpatient oral cyclosporine and showed significant improvement.
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